Post by Ajit Naorem on Apr 17, 2014 10:28:49 GMT 5.5
A new source of blood could be just around the corner: artificial red blood
cells grown from fibroblasts that have been reprogrammed into mature red blood
cells in the lab. The blood, developed by researchers at the University of
Edinburgh and the Scottish National Blood Transfusion Service (SNBTS), would be
Type O negative, also known as universal donor blood, which currently comprises
just 7 percent of the blood donor pool.
“We have made red blood cells that are fit to go in a person’s body,”
project leader Marc Turner, medical director at SNBTS, told Forbes. “Before now, we haven’t really had that.”
The blood is created by dedifferentiating fibroblasts from an adult donor
and reprogramming them into induced pluripotent stem cells (iPSCs), which are
then cultured in a bone-marrow-like environment for a month. Blood cells are
then extracted from the cell culture. If the technique can be scaled up to
industrial levels (which is no trivial task), beyond potentially supplying an
endless supply of life-giving blood, the artificial blood would consist
entirely of young, healthy, and infection-free cells, avoiding the issues of
pathogen contamination that have in the past plagued the donor blood supply.
“Although similar research has been conducted elsewhere, this is the first
time anybody has manufactured blood to the appropriate quality and safety
standards for transfusion into a human being,” Turner told The Telegraph.
The artificial blood could be transfused into patients in a clinical trial
setting as early as 2016, likely for three patients suffering from a genetic
disorder called thalassaemia, in which the body makes unusually low levels of
hemoglobin—a problem that is treated frequent transfusions.
Source: www.the-scientist.com/?articles.view/articleNo/39718/title/Artificial-Blood-Is-Patient-Ready
